Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

About Iso
Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Your Impact
We’re seeking a Senior Research Investigator specialising in biologics drug development to contribute to the pharmacology and translational biology strategy of our novel large molecule therapeutics, harnessing the transformative power of our cutting-edge AI drug design engine. This role requires a unique blend of scientific expertise and the intellectual curiosity to explore uncharted territory in therapeutic design.

Within the Biologics Design and Research team, you will play a pivotal role in our drug discovery projects, working with key internal and external stakeholders to drive the pharmacology strategy of complex projects in early discovery through to candidate selection and, ultimately, advancing candidates towards the clinic.

What You Will Do

• Translational Biology Strategy: Design, execute, and oversee comprehensive pharmacology plans for our large molecule therapeutics.
• In Vivo & In Vitro Evaluation: Lead the design and execution of in vivo efficacy and complex in vitro functional assays to ensure high-quality data generation.
• Drive Project Milestones: Act as the Biology Lead for assigned projects, coordinating complex internal workflows and external CROs to efficiently progress candidates toward critical go/no-go decisions and program milestones.
• New Target Identification: Collaborate with computational biology and design teams to identify, evaluate, and bring new biologics projects into the portfolio, assessing biological feasibility and therapeutic potential.
• Collaborative Platform Building: Partner closely with interdisciplinary teams (ML, Biology, CompBio) to help build our generative AI platform, ensuring the pharmacology data you generate is effectively fed back into design loops.

Essential Skills and Qualifications

• PhD in Immunology, Cancer Biology, Molecular Biology, Biochemistry, Pharmacology or a related scientific discipline.
• 5+ years’ professional experience in an industry role within a biotech or pharma setting.
• A strong scientific expertise in, and in-depth understanding of, disease models and their use in biologics drug development.
• Significant experience in the design and execution of studies to support project progression in the field of biologics drug discovery and development.
• Experience within the immunology, inflammation or oncology therapeutic areas.
• A proficiency with modalities such as multi-specifics or antibody drug conjugates (ADCs).
• Demonstrated proficiency in fostering and managing external collaborations with Contract Research Organizations (CROs).

Nice to Have

• Experience leveraging machine learning or computational biology techniques for biologics design and optimisation.
• Experience in antibody discovery, engineering, and optimisation strategies.
• In-depth understanding of protein structure-function relationships of antibodies.

Hybrid working
We follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in).

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition.